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, (Tielsch, 1961; Rodriguez, 1960; Marino, 1960), (Briguglio, 1962; Martin, 1958).

, , 1954 (Aberasturis, 1954).

, , .. 1933 , . , . , , .. . , , . 1942 , . 3- , , , , +6,0 D 0,3 ( .., 1955).

(Kludas, 1952; Novikova, 1985, Trebula, 1952; Dillon, 1951), -, . - (. HGF), (. IGF), (. FGF), (. EGF), (. NGF), (. CSF) .

, (. EGF) - .

, , .., , ( ).

- , , . , :

- , , (OKeefe, 1985)

, - . (Nath, 2007). , III (Chakraborty, 2005)

, - (TGF), (FGF), (VEGF) (Gwinn, 1976, Hong, 2010)

- , (Duc, 1985)

. , , (Gupta, 2009)

NO, , - (Chakraborty, 2006).

: (, XIII ), - (Shidara, 1984). (

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