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г - 2- 2/ RAPT (Ridogrel Versus Aspirin Patency Trial - г ) ò, .

г , .

- , - 2- - 2. . 糺 98 %. , .

䳿 2.

, , , . , , .

AZD6140

䳿 P2Y12: AZD6140. , P2Y12.

/. . ( ) . , , , IIb/IIIa .

CHAMPION-PCI - , . , 䳿 (, ), 䳿 48 .

AZD6140 - , ( ). AZD6140 P2Y12, . ij , 2-4 .

,

. 䳿 . ij 2 G- (G-protei coupled) , , (protease-activated receptors) - PAR1 PAR4. PAR1 - - ᒺ 䳿 . PAR4 PAR1 .

PAR1, PAR4. 䳿 PAR1 PAR4, , - , .

PAR1 - E5555 SCH530348. E5555 ST, . SCH530348 (, ) TRA^CER ST.

SCH530348 䳿 1 .

糿

, , . , , 䳿 - . ClqTNF- -1, , ³ , .

, , - DZ-697b - , ³ ex vivo. .

, , ³ Ib VI.

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: . . . . . : ϳ / [ . ., . ., . . .]; . . . . . - . : . . ,2011.- 405 .. 2011

㳿 :

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  2. 1.4. ﳿ. 㳿. . . .
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