... .., .. . SoxRS- Escherichia coli // - 2001 - . 66, . 9 - . 1209-1214.

.., .

- // - 2004 - . 69, . 1.- . 16-24.

.., .., .. . .- , 2003 - 328 .

.. , // , . . - 1999. - 9. - . 4-10.

.. // - 2002- Vol.61.-P. 339-352.

Agnez-Lima L.F., Di Mascio ., Demple ., Menck C.F. Singlet molecular oxygen triggers the soxRS regulon of Escherichia coli H Biol. Chem- 2001- Vol. 382 - P. 1071-1075.

Alam J., Wicks C., Stewart D. et al. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor // J. Biol. Chem. - 2000.- Vol. 275.- P. 27694-27702.

Andrews G.K. Regulation of metallothionein gene expression by oxidative stress and metal ions // Biochem. Pharmacol. - 2000. - Vol. 59. - P. 95-104.

Anwar A., Dehn D., Siegel D. et al. Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQOl) with the tumor suppressor protein p53 in cells and cell-free systems // J. Biol. Chem- 2003,- Vol. 278.- P. 10368-10373.

Anwar A., Siegel D., Kepa J.K., Ross D. Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1 // J. Biol. Chem - 2002.- Vol. 277.- P. 14060-14067.

Asher G., Lotem J., Cohen B. et al. Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1 // Proc. Natl. Acad. Sci. USA.- 2001- Vol. 98.- P. 1188-1193.

Awasthi Y.C., Yang Y., Tiwari N.K. et al. Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases // Free Radic. Biol. Med. - 2004 - Vol. 37 - P. 607-619.

Azzi A., Gysin R., Kempna P. et al. Regulation of gene expression by a-tocopherol // Biol. Chem-

- Vol. 385.- P. 585-591.

Bach F.H. Heme oxygenase-1 as a protective gene // Wien. Klin. Wochenschr - 2002 - Vol. 114, Suppl. 4.- P. 1-3.

Balogun E., Hoque ML, Gong P. et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element // Biochem. J.- 2003.- Vol. 371- P. 887-895.

Banning A., Brigelius-Flohe R. NF-kB, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression // Antioxid. Redox. Signal - 2005 - Vol. 7 - P. 889-899.

Banning A., Deubel S., Kluth D. et al. The GI-GPx gene is a target for Nrf2 // Mol. Cell. Biol-

- Vol. 25.- P. 4914-4923.

Barch D.H., Rundhaugen L.M. Ellagic acid induces NAD(P)H:quinone reductase through activation of the antioxidant responsive element of the rat NAD(P)H:quinone reductase gene // Carcinogenesis - 1994-Vol.

15-P. 2065-2068.

Basu M.K., Koonin E.V. Evolution of eukaryotic cysteine sulfinic acid reductase, sulfiredoxin (Srx), from bacterial chromosome partitioning protein ParB // Cell Cycle - 2005 - Vol. 4- P.947-952.

Bea F., Hudson F.N., Chait A. et al. Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements // Circ. Res-

- Vol. 92.- P. 386-393.

Belli G., Molina M.M., Garcia-Martinez J. et al. Saccharomyces cerevisiae glutaredoxin 5-deficient cells subjected to continuous oxidizing conditions are affected in the expression of specific sets of genes // J. Biol. Chem.- 2004.- Vol. 279.- P. 12386-12395.

Ben-Dor A., Steiner M., Gheber L. et al. Carotenoids activate the antioxidant response element transcription system // Mol. Neurobiol - 2005 - Vol. 4 - P. 177-186.

Bi Y., Palmiter R.D., Wood K.M., Ma Q. Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc // Biochem. J - 2004- Vol. 380- P. 695-703.

Bloom D.A., Jaiswal A.K. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element- mediated NAD(P)H:quinone oxidoreductase-1 gene expression // J. Cell. Mol. Med - 2003 - Vol. 278.- P. 44675-44682.

Buckley B.J., Marshall Z.M., Whorton A.R. Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothelium // Biochem. Biophys. Res. Commun - 2003 - Vol. 307- P. 973-979.

Calkins M.J., Jakel R.J., Johnson D.A. et al. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription // Proc. Natl. Acad. Sci. USA.- 2005 - Vol. 102- P. 244-249.

Campagne M.V., Thibodeaux H., van Bruggen N. et al. Increased binding activity at an antioxi- dant-.esponsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion // J. Neurosci- 2000.- Vol. 20.- P. 5200-5207.

Carvan M.J., Solis W.A., Gedamu L., Nebeit D.W. Activation of transcription factors in zebrafish cell cultures by environmental pollutants // Arch. Biochem. Biophys - 2000 - Vol. 376 - P. 320-327.

Chan J.Y., Kwong M. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein // Biochim. Biophys. Acta. - 2000- Vol. 1517.-P. 19-26.

Chan J.Y., Kwong M., Lu R., Chang J. et al. Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice // EMBO J - 1998 - Vol.

- P.1779-1787.

Chan K., Han X.D., Kan Y.W. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen // Proc. Natl. Acad. Sci. USA. - 2001 - Vol. 98 - P. 4611-4616.

Chan K., Kan Y.W. Nrf2 is essential for protection against acute pulmonary injury in mice // Proc. Natl. Acad. Sci. USA.- 1999.- Vol. 96.-P. 12731-12736.

Chan K., Lu R., Chang J.C., Kan Y.W. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development // Proc. Natl. Acad. Sci. USA- 1996.- Vol. 93.- P. 13943-13948.

Chan T.S., Teng S., Wilson J.X. et al. Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase l(NQOl) // Free Radic. Res- 2002.- Vol. 36.-P.421-427.

Chanas S.A., Jiang Q., McMahon M. et al. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gstal, Gsta2, Gstml, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice // Biochem. J- 2002- Vol. 365.-P.405-416.

Chen C., Yu R., Owuor E.D., Kong A.N. Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death // Arch. Pharm. Res - 2000.- Vol. 23.- P.605-612.

Chen X.-L., Kunsch C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases // Curr. Pharm. Des.- 2004.- Vol. 10.- P. 879-891.

Chen X.-L., Varner S.E., Rao A.S. et al. Laminar flow induction of antioxidant response element- mediated genes in endothelial cells: A novel anti-inflammatory mechanism // J. Biol. Chem.- 2003- Vol. 278.- P. 703-711.

Cheng J.Z., Sharma R., Yang Y. et al. Accelerated metabolism and exclusion of 4-hydroxynoncnal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress // J. Biol. Chem.- 2001.- Vol. 276.- P. 41213-41223.

Cho H.Y., Jedlicka A.E., Reddy S.P. et al. Role of NRF2dn protection against hyperoxic lung injury in mice // Am. J. Respir. Cell Mol. Biol - 2002 - Vol. 26 - P. 175-182.

Cho H.-Y., Reddy S.P., DeBiase A. et al. Gene expression profiling of NRF2-mediated protection against oxidative injury // Free Radic. Biol. Med - 2005 - Vol. 38 - P. 325-343.

Cho H.Y., Reddy S.P., Yamamoto M., Kleeberger S.R. The transcription factor NRF2 protects against pulmonary fibrosis // FASEB J - 2004 - Vol. 18 - P. 1258-1260.

Cho S., Urata Y., Iida T. et al. Glutathione downregulates the phosphorylation of I kappa B: autoloop regulation of the NF-kappa B-mediated expression of NF-kappa B subunits by TNF-alpha in mouse vascular endothelial cells // Biochem. Biophys. Res. Commun - 1998 - Vol. 253 - P. 104-108.

Christman M.F., Morgan R.W., Jacobson F.S., Ames B.N. Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium // Cell.- 1985 - Vol. 41.- P. 753-762.

Collett G.P., Campbell F.C. Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells // Carcinogenesis. - 2004.- Vol. 25- P. 2193-2189.

Cullinan S.B., Diehl J.A. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress // J. Biol. Chem - 2004 - Vol. 279 - P. 20108-20117.

.Cullinan S.B., Zhang D., Hannink M. et al. Nrf2 is a direct PERK substrate and effector of PERK-

dependent cell survival // Mol. Cell. Biol. - 2003.- Vol. 23.- P. 7198-7209.

Den Hertog J., Groen A., van der Wijk T. Redox regulation of protein-tyrosine phosphatases // Arch. Biochem. Biophys .- 2005- Vol. 434 - P. 11-15.

Dhakshinamoorthy S., Jain A.K., Bloom D.A., Jaiswal A.K. Bachl competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants // J. Biol. Chem.- 2005- Vol. 280.-P. 16891-16900.

Dhakshinamoorthy S., Jaiswal A.K. Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:quinone oxidoreductase 1 gene// J. Biol. Chem - 2000 - Vol. 275 - P. 40134-40141.

Dhakshinamoorthy S., Long D.J., Jaiswal A.K. Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens // Curr. Top. Cell Regul - 2000 - Vol. 36.- P. 201-216.

Dickinson D.A., lies K.E., Zhang H. et al. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression // FASEB J - 2003- Vol. 17 - P. 473-475.

Dickinson D.A., Levonen A.L., Moellering D.R.et al. Human glutamate cysteine ligase gene regula-

tion through the electrophile response element // Free Radic. Biol. Med2004 - Vol. 37 - P. 11 Sill 59.

Dinkova-Kostova A.T., Fahey J.W., Talalay P. Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQOl) // Meth. Enzymol- 2004 - Vol. 382 - P. 423-448.

Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N. et al. Direct evidence that sulfhydryl groups of Keapl are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants // Proc. Natl. Acad. Sci. USA.- 2002.- Vol. 99.- P. 11908-11913.

Dinkova-Kostova A.T., Holtzclaw W.D., Wakabayashi N. Keapl, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein // Biochemistry - 2005- Vol. 44.- P. 6889-6899.

Dinkova-Kostova A.T., Liby K.T., Stephenson K.K. et al. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress // Proc. Natl. Acad. Sci. USA.- 2005.- Vol. 102.- P. 4584-4589.

Dinkova-Kostova A.T., Massiah M.A., Bozak R.E. et al. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups // Proc. Natl. Acad. Sci. USA - 2001- Vol. 98 - P. 3404-3409.

Dinkova-Kostova A.T., Talalay P. Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen // Free Radic. Biol. Med. - 2000.- Vol. 29.- P. 231-240.

Dukan S., Dadon S. Smulski D.R., Belkin S. Hypochlorous acid activates the heat shock and soxRS systems of Escherichia coli // Appl. Environ. Microbiol - 1996 - Vol. 62 - P. 4003-4008.

Eggler A.L., Liu G., Pezzuto J.M. et al. Modifying specific cysteines of the electrophile-sensing human Keapl protein is insufficient to disrupt binding to the Nrf2 domain Neh2 // Proc. Natl. Acad. Sci. USA.- 2005.- Vol. 102.- P. 10070-10075.

Fimognari C., Nusse M., Cesari R. et al. Growth inhibition, cell-cycle arrest and apoptosis in human T- cell leukemia by the isothiocyanate sulforaphane // Carcinogenesis - 2002 - Vol. 23 - P. 581-586.

Finley J.W. The antioxidant responsive element (ARE) may explain the protective effects of cruciferous vegetables on cancer // Nutr. Rev. - 2003 - Vol. 61- P. 250-254.

Forman H.J., Dickinson D.A., lies K.E. HNE-signaling pathways leading to its elimination // Mol. Aspects Med. - 2003. - Vol. 24. - P. 189-194.

Forman H.J., Fukuto J.M., Tones M. Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers//Am. J. Physiol. Cell Physiol.-2004-Vol. 287-P. C246-256.

Gaikwad A., Long D.J. 2nd, Stringer J.L., Jaiswal A.K. In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQOl) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue // J. Biol. Chem.- 2001.- Vol. 276.- P. 22559-22564.

Galloway D.C., McLellan L.I. Inducible expression of the y-glutamylcysteine synthetase light subunit by r-butylhydroquinone in HepG2 cells is not dependent on an antioxidant-responsive element // Biochem. J. - 1998.- Vol. 336, Pt. 3.- P. 535-539.

Gius D., Botero A., Shah S., Curry H.A. Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1 // Toxicol. Lett. - 1999 - Vol. 106 - P. 93-106.

Gong P., Hu B., Stewart D. Cobalt induces heme oxygenase-1 expression by a hypoxia-inducible factor-independent mechanism in Chinese hamster ovary cells. Regulation by Nrf2 and MafG transcription factors // J. Biol. Chem. - 2001.- Vol. 276 - P. 27018-27025.

Hansen J.M., Watson W.H., Jones D.P. Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1 // Toxicol. Sci - 2004.- Vol. 82,- P. 308-317.

Hatayama I., Satoh K., Sato K. Developmental and hormonal regulation of the major form of hepatic glutathione S-transferase in male mice // Biochem. Biophys. Res. Commun- 1986 - Vol. 140 - P. 581-588.

Hayashi A., Suzuki H., Itoh K. et al. Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts // Biochem. Biophys. Res. Commun - 2003 - Vol. 310 - P. 824-829.

Hayes J.D., Chanas S.A., Henderson C.J. et al. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopre- ventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin // Biochem. Soc. Trans.- 2000.- Vol. 28.- P. 33-41.

Hayes J.D., Flanagan J.U., Jowsey I.R. Glutathione transferases // Annu. Rev. Pharmacol. Toxicol- 2005.- Vol. 45.-P.51-88.

Hayes J.D., McMahon M. Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention // Cancer Lett.- 2001- Vol. 174.- P. 103-113.

Hayes J.D., Pulford D.J., Ellis E.M. et al. Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1 // Chem. Biol. Interact. - 1998.-Vol. 111-112.-P.51-67.

Hess A., Wijayanti N., Neuschafer-Rube A.P. et al. Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway // J. Biol. Chem.- 2003 - Vol. 278 - P. 45419-45434.

Hintze K.J., Keck A.S., Finley J.W., Jeffery E.H. Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepalclc7 cells and in male Fisher 344 rats // J. Nutr. Biochem.- 2003- Vol. 14.-P. 173-179.

Hintze K.J., Wald K., Finley J.W. Phytochemicals in broccoli transcriptionally induce thioredoxin reductase // J. Agric. Food Chem. - 2005 - Vol. 53 - P. 5535-5540.

Hintze K.J., Wald K.A., Zeng H. et al. Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element // J. Nutr.- 2003.- Vol. 133.- P. 2721-2727.

Hirota A., Kawachi Y., Itoh K. et al. Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective role in UVA-induced apoptosis // J. Invest. Dermatol. - 2005- Vol. 124.-P. 825-832.

Hou D.X., Fukuda M., Johnson J.A. et al. Fisetin induces transcription of NADPH:quinone oxidore- ductase gene through an antioxidant responsive element-involved activation // Int. J. Oncol - 2001- Vol. 18.-P. 1175-1179.

Hu R., Hebbar V., Kim B.-R. et al. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat // J. Pharmacol. Exp. Ther.- 2004- Vol. 310 - P. 263-271.

Huang H.C., Nguyen T., Pickett C.B. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription // J. Biol. Chem - 2002-Vol. 277 - P. 42769-42774.

Iida T., Mori E., Mori K. et al. Co-expression of y-glutamylcysteine synthetase sub-units in response to cisplatin and doxorubicin in human cancer cells // Int. J. Cancer - 1999.- Vol. 82 - P. 405-411.

Ikeda H., Serria M.S., Kakizaki I. et al. Activation of mouse Pi-class glutathione S-transferase gene by Nrf2(NF-E2-related factor 2) and androgen // Biochem. J. - 2002 - Vol. 364 - P. 563-570.

Ikner A., Shiozaki K. Yeast signaling pathways in the oxidative stress response // Mutât. Res-

-Vol. 569.- P. 13-27.

Imbert V., Rupee R.A., Livolsi A. et al. Tyrosine phosphorylation of I kappa B-alpha activates NF- kappa B without proteolytic degradation of I kappa B alpha // Cell. - 1996. - Vol. 86. - P. 787-798.

Immenschuh S., Baumgart-Vogt E. Peroxiredoxins, oxidative stress, and cell proliferation // Antioxid. Redox Signal.- 2005.- Vol. 7.- P. 768-777.

Inamdar N.M., Ahn Y.I., Alam J. The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for Maf and NF-E2 transcription factors // Biochem. Biophys. Res. Commun - 1996 - Vol. 221- P. 570-576.

Iqbal M, Okada S. Induction of NAD(P)H:quinone reductase by probucol: a possible mechanism for protection against chemical carcinogenesis and toxicity // Pharmacol. Toxicol - 2003 - Vol. 93 - P. 259-263.

lshii T., Itoh K., Ruiz E. et al. Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: Activation by oxidatively modified LDL and 4-hydroxynonenal // Circ. Res.- 2004.- Vol. 94.- P. 609-616.

lshii T., Itoh K., Sato H., Bannai S. Oxidative stress-inducible proteins in macrophages // Free Radie. Res. - 1999.- Vol. 31.- P. 351-355.

lshii T., Itoh K., Takahashi S. et al. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages // J. Biol. Chem - 2000 - Vol. 275 - P. 16023-16029.

Itoh K., Chiba T., Takahashi S. et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements // Biochem. Biophys. Res. Commun.- 1997.- Vol. 236.- P. 313-322.

Itoh K., Ishii T., Wakabayashi N., Yamamoto M. Regulatory mechanisms of cellular response to oxidative stress // Free Radic. Res - 1999- Vol. 31.- P. 319-324.

Itoh K., Mochizuki ML, Ishii Y. et al. Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-A12,14-prostaglandin J2 // Mol. Cell. Biol - 2004 - Vol. 24 - P. 36-45.

Itoh K., Tong K.I., Yamamoto M. Molecular mechanism activating Nrf2-Keapl pathway in regulation of adaptive response to electrophiles // Free Radic. Biol. Med - 2004 - Vol. 36 - P. 1208-1213.

Itoh K., Wakabayashi N., Katoh Y., et al. Keapl represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain//Genes Dev-1999-Vol. 13 - P. 76-78.

Jackson M.J., Papa S., Bolanos J. et al. Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function // Mol. Aspects Med - 2002,- Vol. 23- P. 209-285.

Jacob C., Giles G.I., Giles N.M., Sies H. Sulfur and selenium: the role of oxidation state in protein structure and function // Angew. Chem. Int. Ed. Engl - 2003 - Vol. 42 - P. 4742-4758.

Jacob C., Holme A.L., Fry F.H. The sulfinic acid switch in proteins // Org. Biomol. Chem.- 2004- Vol. 2.-P. 1953-1956.

Jaiswal A.K. Regulation of genes encoding NAD(P)H:quinone oxidoreductases // Free Radcal. Biol. Med.- 2000.- Vol. 29.- P. 254-262.

Jaiswal A.K., Venugopal R., Mucha J. et al. Caffeic acid phenethyl ester stimulates human antioxidant response element-mediated expression of the NAD(P)H:quinone oxidoreductase (NQOl) gene // Cancer Res.- 1997.- Vol. 57.- P. 440-446.

Jeong W.S., Keum Y.S., Chen C. et al. Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells // J. Biochem. Mol. Biol. - 2005.- Vol. 38.- P. 167-176.

Jeyapaul J., Jaiswal A.K. Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma-glutamylcysteine synthetase heavy subunit gene // Biochem. Pharmacol.- 2000.- Vol. 59.- P. 1433-1439.

Kakishita H., Hattori Y. Vascular smooth muscle cell activation and growth by 4-hydroxynonenal // Life Sci. - 2001.- Vol. 69.- P. 689-697.

Kamata H., Manabe T., Oka S. et al. Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops // FEBS Lett. - 2002 - Vol. 519 - P. 231-237.

Kang K.W., Choi S.H., Kim S.G. Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-transferase A2 induction // Nitric Oxide - 2002 - Vol. 7 - P. 244-253.

Kang K.W., Ryu J.H., Kim S.G. The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells // Mol. Pharmacol. - 2000 - Vol. 58 - P. 1017-1025.

Kataoka K., Handa H., Nishizawa M. Induction of cellular antioxidative stress genes through het- erodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds // J. Biol. Chem.- 2001.- Vol. 276.- P. 34074-34081.

Katoh Y., Itoh K., Yoshida E. et al. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription // Genes Cells - 2001- Vol. 6 - P. 857-868.

Katsuoka F., Motohashi H., Engel J.D., Yamamoto M. Nrf2 transcriptionally activates the mafG gene through an antioxidant response element // J. Biol. Chem - 2005 - Vol. 280 - P. 4483-4490.

Kawamoto Y., Nakamura Y., Naito Y. et al. Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-induced expression of glutathione S-transferases // J. Biol. Chem. - 2000.- Vol. 275.- P. 11291-11299.

Kim M.Y., Song K.S., Park G.H. et al. B6C3F1 mice exposed to ozone with 4-(N-methyl-N- nitrosamino)-l-(3-pyridyl)-l-butanone and/or dibutyl phthalate showed toxicities through alterations of NF-kB, AIM, Nrf2, and osteopontin// J. Vet. Sci - 2004 - Vol. 5.-P. 131-137.

Kim S.G., Kim S.O. PKC downstream of P13-kinase regulates peroxynitrite formation for Nrf2- mediated GSTA2 induction // Arch. Pharm. Res - 2004 - Vol. 27 - P. 757-762.

Kim Y.C., Masutani H., Yamaguchi Y. et al. Hemin-induced activation of the thioredoxin gene by

Nif2. A differential regulation of the antioxidant responsive element by a switch of its binding factors // J. Biol. Chem.- 2001.- Vol. 276.- P. 18399-18406.

Kim Y.C., Yamaguchi Y., Kondo N. et al. Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response // Oncogene.- 2003 - Vol. 22.- P. 1860- 1865.

Kitamuro T., Takahashi K., Ogawa K. et al. Bachl functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells // J. Biol. Chem - 2003 - Vol. 278 - P. 9125-9133.

Kobayashi M., Itoh K., Suzuki T. et al. Identification of the interactive interface and phylogenie conservation of the Nrf2-Keapl system // Genes Cells - 2002 - Vol. 7 - P. 807-820.

Kondo T., Higashiyama Y., Goto S. et al. Regulation of y-glutamylcysteine synthetase expression in response to oxidative stress // Free Radie. Res - 1999- Vol. 31- P. 325-334.

Kong A.N., Owuor E., Yu R. et al. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE) // Drug Metab. Rev - 2001,- Vol.

- P. 255-271.

Korhonen R., Lahti A., Kankaanranta H., Moilanen E. Nitric oxide production and signaling in inflammation // Curr. Drug Targets lnflamm. Allergy - 2005- Vol. 4 - P. 471-479.

Kotlo K.U., Yehiely F., Efimova E. et al. Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells // Oncogene.- 2003.- Vol. 22.- P. 797-806.

Kraft A.D., Johnson D.A., Johnson J.A. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult // J. Neurosci- 2004 - Vol. 24 - P. 1101-1112.

Kuo P.C., Abe K., Schroeder R.A. Superoxide enhances interleukin ip-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene // Gastroenterology.- 2000 - Vol. 118 - P. 608-618.

Kwak M.-K., Wakabayashi N., Itoh K., Motohashi H., Yamamoto M., Kensler T.W. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keapl-Nrf2 pathway: Identification of novel gene clusters for cell survival // J. Biol. Chem - 2003 - Vol. 278 - P. 8135-8145.

Lavrovsky Y., Chatterjee B., Clark R.A., Roy A.K. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases // Exp. Gerontol - 2000 - Vol. 35 - P. 521-532,

Let J.M., Calkins M.J., Chan K. et al. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis // J. Biol. Chem.- 2003 - Vol. 278 - P. 12029-12038.

Let J.M., Chan K., Kan Y.W., Johnson J.A. Targeted disruption of Nrf2 causes regenerative im- mune-mediated hemolytic anemia // Proc. Natl. Acad. Sci. USA.- 2004 - Vol. 101- P. 9751-9756.

Let J.M., Li J., Johnson D.A. et al. Nrf2, a multi-organ protector? // FASEB J - 2005.- Vol. 19 - P, 1061-1066.

Let J.M., Moehlenkamp J.D., Hanson J.M., Johnson J.A. Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinoi;.e is independent of oxidative stress in IMR-32 human neuroblastoma cells // Biochem. Biophys. Res. Commun - 2001 - Vol. 280 - P. 286-292.

Lee J.M., Shih A.Y., Murphy T.H., Johnson J.A. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons // J. Biol. Chem - 2003 - Vol. 278 - P. 37948-37956.

Lee J.R., Koretzky G.A. Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes // Eur. J, Immunol.- 1998.- Vol. 28.- P. 4188-4197.

Levonen, A.L., Landar, A., Ramachandran, A., Ceaser, E.K., Dickinson, D.A., Zanoni, G., Morrow, J.D., and Darley-Usmar, V.M. (2004) Biochem. 7., 378, 373-382.

Li J., Johnson D., Calkins M., Wright, L., Svendsen, C., and Johnson, J. (2005) Toxicol. Sci., 83, 313-328.

Li J., Let J.-M., Johnson J.A. Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells // J. Biol. Chem.- 2002.- Vol. 277.- P. 388-394.

Li N., Alam J., Venkatesan M.I. et al. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals // J. Immunol - 2004 - Vol. 173 - P. 3467-3481.

Li N., Karin M. Ionizing radiation and short wavelength UV activate NF-kB through two distinct mechanisms//Proc. Natl. Acad. Sci. USA - 1998 - Vol. 95-P. 13012-13017.

Li N., Karin M. Is NF-kB the sensor of oxidative stress? // FASEB J - 1999- Vol. 13 - P. 1137-1143.

Li Q., Verma l.M. NF-kB regulation in the immune system // Nat. Rev. Immunol - 2002 - Vol. 2- P. 725-734.

Liou H.-C., Hsia C.Y. Distinctions between c-Rel and other NF-kB proteins in immunity and disease // BioEssays.- 2003.- Vol. 25.- P. 767-780.

Long D.J. 2nd, Gaikwad A., Multani A. et al. Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQOl) gene in mice causes myelogenous hyperplasia // Cancer Res - 2002 - Vol. 62 - P. 3030-3036.

Long D.J. 2nd, Jaiswal A.K. NRH:quinone oxidoreductase2 (NQ02) // Chem. Biol. Interact.- 2000.- Vol. 129.-P. 99-112.

Long D.J. 2nd, Waikel R.L., Wang X.J. et al. NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin // J. Natl. Cancer Inst.- 2001.- Vol. 93.- P. 1166-1170.

Marshall H.E., Hess D.T., Stamler J.S. S-nitrosylation: Physiological regulation of NF-kB // Proc. Natl. Acad. Sci. USA.- 2004.- Vol. 101.-P. 8841-8842.

Marshall H.E., Stamler J.S. Nitrosative stress-induced apoptosis through inhibition of NF-kB // J. Biol. Chem.- 2002.- Vol. 277.- P. 34223-34228.

Marini M.G., Chan K., Casula L. et al. hMAF, a small human transcription factor that heterodimer- izes specifically with Nrfl and Nrf2 // J. Biol. Chem - 1997- Vol. 272 - P. 16490-16497.

Mathers J., Fraser J.A., McMahon M. et al. Antioxidant and cytoprotective responses to redox stress // Biochem. Soc. Symp.- 2004.- Vol. 71.- P. 157-176.

Matthews J.R., Wakasugi N., Virelizier J.L. et al. Thioredoxin regulates the DNA binding capacity of NFkB by reduction of a disulside bond involving cysteine 62 // Nucleic Acids - 1992 - Vol. 20- P. 3821-3830.

McWalter G.K., Higgins L.G., McLellan L.I. et al. Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by Broccoli seeds and isothiocyanates // J. Nutr.- 2004 - Vol. 134,- P. 3499S-3506S.

Miao W., Hu L., Kandouz M:, Batist G. Oltipraz is a bifunctional inducer activating both phase I and phase II drug-metabolizing enzymes via the xenobiotic responsive element // Mol. Pharmacol-

- Vol. 64.- P. 346-354.

Minekura H., Kumagai T., Kawamoto Y. 4-Hydroxy-2-nonenal is a powerful endogenous inhibitor of endothelial response // Biochem. Biophys. Res. Commun - 2001.- Vol. 282 - P. 557-561.

Misiewicz I., Skupinska K., Kowalska E. et al. Sulforaphane-mediated induction of a phase 2 detoxifying enzyme NAD(P)H:quinone reductase and apoptosis in human lymphoblastoid cells // Acta Biochim. Pol.- 2004.- Vol. 51.- P. 711-72 L

Mochizuki M., Ishii Y., Itoh K. et al. Role of 15-deoxy-A12,14-prostaglandin J2-prostaglandin J2 and Nrf2 pathways in protection against acute lung injury // Am. J. Respir. Crit. Care Med - 2005- Vol. 171.-P. 1260-1266.

Morales A., Garcia-Ruiz C., Miranda M. et al. Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase // J. Biol. Chem.- 1997.- Vol. 272.- P. 30371-30379.

Morimitsu Y., Nakagawa Y., Hayashi K. et al. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway // J. Biol. Chem - 2002.- Vol. 277.- P. 3456-3463.

Morito N., Yoh K., Itoh K. et al. Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels // Oncogene - 2003- Vol. 22 - P. 9275-9281.

Motohashi H., Yamamoto M. Nrf2-Keapl defines a physiologically important stress response mechanism // Trends Mol. Med - 2004 - Vol. 10 - P. 549-557.

Mulcahy R.T., Wartman M.A., Bailey H.H., Gipp J.J. Constitutive and (3-naphthoflavone-induced expression of the human y-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence // J. Biol. Chem.- 1997- Vol. 272 - P. 7445-7454.

Murphy T.H., Yu J., Ng R. et al. Preferential expression of antioxidant response element mediated gene expression in astrocytes // J. Neurochem- 2001Vol. 76 - P. 1670-1678.

Nakaso K., Yano H., Fukuhara Y. et al. PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells // FEBS Lett - 2003 - Vol. 546 - P. 181-184.

Naughton P., Hoque M., Green C.J. et al. Interaction of heme with nitroxyl or nitric oxide amplifies heme oxygenase-1 induction: involvement of the transcription factor Nrf2 // Cell Mol. Biol.- 2002- Vol. 48.- P. 885-894.

Nguyen T., Sherratt P.J., Huang H.-C. et al. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: Degradation of Nrf2 by the 26 S proteasome // J. Biol. Chem- 2003.- Vol. 278 - P. 4536-4541.

Nguyen T., Sherratt P.J., Pickett C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element // Annu. Rev. Pharmacol. Toxicol - 2003 - Vol. 43 - P. 233-260.

Nioi P., Hayes J.D. Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the aryl hydrocarbon receptor basic helix-loop-helix transcription factors // Mutât. Res - 2004 - Vol. 555 - P. 149-171.

Numazawa S., Ishikawa M., Yoshida A. et al. Atypical protein kinase C mediates activation of NF- E2-related factor 2 in response to oxidative stress // Am. J. Physiol. Cell Physiol.- 2003- Vol. 285.- P. C334-C342.

Nunoshiba T., Hidalgo E., Cuevas C.F.A., Demple B. 2-stage control of an oxidative stress regulon: The Escherichia-coli soxR protein triggers redox-inducible expression of the soxS regulatory gene // J. Bacteriol- 1992.-Vol. 174.-P. 6054-6060.

Ohtsubo T., Kamada S., Mikami T. et al. Identification of NRF2, a member of the NF-E2 family of transcription factors, as a substrate for caspase-3(-like) proteases // Cell Death. Differ- 1999- Vol. 6.- P. 865-872.

Oka S., Kamata H., Kamata K. et al. N-acetylcysteine suppresses TNF-induced NF-kB activation through inhibition of IkappaB kinases // FEBS Lett - 2000 - Vol. 472 - P. 196-202.

Paget M.S., Buttner M.J. Thiol-based regulatory switches // Annu. Rev. Genet - 2003 - Vol. 37 - P. 91-121.

Park E.Y., Rho H.M. The transcriptional activation of the human copper/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element // Mol. Cell. Biochem.- 2002 - Vol. 240 - P. 47-55.

Park I.N., Cho I.J., Kim S.G. Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression // Drug Metab. Dispos - 2004- Vol. 32 - P. 893-897.

Parola M., Bellomo G., Robino G. 4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications // Antioxid. Redox. Signal - 1999 - Vol. 1- P. 255-284.

Pfeilschifter J., Eberhardt W., Beck K.F. Regulation of gene expression by nitric oxide // Pflugers Arch.- 2001.- Vol. 442.- P. 479-486.

Pietsch E.C., Chan J.Y., Torti F.M., Torti S.V. Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones // J. Biol. Chem - 2003 - Vol. 278 - P. 2361-2369.

Poole L.B., Karplus P.A., Claiborne A. Protein sulfenic acids in redox signaling // Annu. Rev. Pharmacol. Toxicol.- 2004.- Vol. 44.- P. 325-347.

Poss K.D., Tonegawa S. reduced stress defense in heme oxygenase 1 - deficient cells // Proc. Natl. Acad. Sci. USA.- 1997.- Vol. 94.- P. 10925-10930.

Prestera T., Holtzclaw W.D., Zhang Y., Talalay P. Chemical and molecular regulation of enzymes that detoxify carcinogens // Proc. Natl. Acad. Sci. USA - 1993- Vol. 90 - P. 2965-2969.

Prestera T., Talalay P. Electrophile and antioxidant regulation of enzymes that detoxify carcinogens // Proc. Natl. Acad. Sci. USA.- 1995.- Vol. 92.- P. 8965-8969.

Prochaska H.J., De Long M.J., Talalay P. On the mechanisms of induction of cancer-protective enzymes: A unifying proposal // Proc. Natl. Acad. Sci. USA - 1985 - Vol. 82 - P. 8232-8236.

Rahman I., MacNee W. Oxidative stress and regulation of glutathione in lung inflammation // Eur. Respir. J.- 2000.- Vol. 16.- P. 534-554.

Ramos-Gomez M., Kwak M.K., Dolan P.M. et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrj2 transcription factor-deficient mice // Proc. Natl. Acad. Sci. USA.- 2001.- Vol. 98.- P. 3410-3415.

Rangasamy T., Cho C.Y., Thimmulappa R.K. et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice // J. Clin. Invest - 2004 - Vol. 114.- P. 1248-1259.

Ren Y., Smith A. Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and c/s-acting elements // J. Biol. Chem.- 1995- Vol. 270- P. 23988-23995.

Renard P., Zachary M.D., Bougelet C. et al. Effects of antioxidant enzyme modulations on interleukin- 1-induced nuclear factor kappa B activation // Biochem. Pharmacol - 1997- Vol. 53.- P. 149-160.

Rodrigues-Pousada C., Nevitt T., Menezes R. The yeast stress response. Role of the Yap family of b- ZIP transcription factors. The PABMB lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw // FEBS J.- 2005.- Vol. 272.- P. 2639-2647.

Ross D., Kepa J.K., Winski S.L. et al. NAD(P)H:quinone oxidoreductase 1 (NQOl): chemoprotec- tion, bioactivation, gene regulation and genetic polymorphisms // Chem. Biol. Interact - 2000 - Vol. 129.- P. 77-97.

Ruis H., Schuller C. Stress signaling in yeast // Bioessays.- 1995- Vol. 17 - P. 959-965.

Rushmore T.H., Morton M.R., Pickett C.B. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity // J. Biol. Chem.- 1991.- Vol. 266.- P. 11632-11639.

Rushmore T.H., Pickett C.B. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants // J. Biol. Chem - 1990 - Vol. 265- P.14648-14653.

Sakurai A., Nishimoto M., Himeno S. et al. Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF-E2-related factor-2 // J. Cell. Physiol. - 2005.- Vol. 203.- P. 529-537.

Sankaranarayanan K., Jaiswal A.K. Nrf3 negatively regulates antioxidant-response element- mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase 1 gene // J. Biol. Chem.- 2004.- Vol. 279.- P. 50810-50817.

Sasaki H., Sato H., Kuriyama-Matsumura K. et al. Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression // J. Biol. Chem.- 2002 - Vol. 277- P. 44765-44771.

Sassa S. Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide? // Anti- oxid. Redox. Signal.- 2004.- Vol. 6.- P. 819-824.

Schenk H., Klein M., Erdbrugger W. et al. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kB and AP-1 // Proc. Natl. Acad. Sci. USA - 1994- Vol. 91- P. 1672-1676.

Schmidt K.N., Amstad P., Cerutti P., Baeuerle P.A. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kB // Chem. Biol - 1995- Vol. 2 - P. 13-22.

Schreck R., Grassmann R., Fleckenstein B., Baeuerle P.A. Antioxidants selectively suppress activation of NF-kB by human T-cell leukemia virus type I Tax protein // J. Virol.- 1992 - Vol. 66 - P. 6288-6293.

Schreck R., Rieber P., Baeuerle, P.A., 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1 // EMBO J - 1991- Vol. 10.-P. 2247-2258.

Sen R., Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences // Cell.- 1986.- Vol. 46.- P. 705-716.

Shan Y., Lambrecht R.W., Ghaziani T. Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS // J. Biol. Chem - 2004 - Vol. 279 - P. 51769-51774.

Sharrna R., Yang Y., Sharma A. et al. Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis // Antioxid. Redox. Signal-

- Vol. 6.- P. 289-300.

Shaulian E., Karin M. AP-1 as a regulator of cell life and death // Nat. Cell Biol - 2002- Vol. 4 - P. El 31El 36.

Shih A.Y., Johnson D.A., Wong G. et al. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress // J. Neurosci - 2003- Vol. 23.- P. 3394-3406.

Siegel D., Gustafson D.L., Dehn D.L. et al. NAD(P)H:Quinone oxidoreductase 1: Role as a superoxide scavenger // Mol. Pharmacol - 2004.- Vol. 65- P. 1238-1247.

Stewart D., Killeen E., Naquin R. et al. Degradation of transcription factor Nrf2 via the ubiquitin- proteasome pathway and stabilization by cadmium // J. Biol. Chem- 2003 - Vol. 278 - P. 2396-2402.

Sun J., Hoshino H., Takaku K. et al. Hemoprotein Bachl regulates enhancer availability of heme oxygenase-1 gene // EMBO J.- 2002.- Vol. 21.- P. 5216-5224.

Sun X., Erb H., Murphy T.H. Coordinate regulation of glutathione metabolism in astrocytes by Nrf2 // Biochem. Biophys. Res. Commun - 2005- Vol. 326 - P. 371-377.

Sun Y., Oberley L.W. Redox regulation of transcriptional activators // Free Radie. Biol. Med. - 1996.- Vol. 21.-P. 335-348.

Suzuki H., Tashiro S., Sun J. et al. Cadmium induces nuclear export of Bachl, a transcriptional repressor of heme oxygenase-1 gene // J. Biol. Chem.- 2003 - Vol. 278.- P. 49246-49253.

Suzuki T., Takagi Y., Osanai H. et al. Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish // Biochem. J - 2005 - Vol. 388, Pt. l.-P. 65-73.

Takada Y., Mukhopadhyay A., Kundu G.C. et al. Hydrogen peroxide activates NF-kB through tyrosine phosphorylation of IkBcc and serine phosphorylation of p65: evidence for the involvement of IkBcc kinase and Syk protein-tyrosine kinase // J. Biol. Chem - 2003.- Vol. 278 - P. 24223-24241.

Talalay P., De Long M.J., Prochaska H.J. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis // Proc. Natl. Acad. Sci. USA- 1988.- Vol. 85.- P. 8261-8265.

Talalay P., Dinkova-Kostova A.T. Role of nicotinamide quinone oxidoreductase 1 (NQOl) in protection against toxicity of electrophiles and reactive oxygen intermediates // Meth. Enzymol - 2004- Vol. 382.- P. 355-364.

Talalay P., Fahey J.W. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism// J. Nutr - 2001- Vol. 131- P. 3027S-3033S.

Tanito M., Masutani H., Kim Y.C. et al. Sulforaphane induces thioredoxin through the antioxidant- responsive element and attenuates retinal light damage in mice // Invest. Ophthalmol. Vis. Sci-

- Vol. 46.- P. 979-987.

Tarumoto T., Nagai T., Ohmine K. et al. Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line // Exp. Hematol - 2004- Vol. 32.- P. 375-381.

Thimmulappa R.K., Mai K.H., Srisuma S. et al. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray // Cancer Res - 2002 - Vol. 62.- P.5196-5203.

Tjalkens R.B., Luckey S.W., Kroll D.J., Petersen D.R. Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element // Arch. Biochem. Biophys - 1998 - Vol. 359 - P. 42-50.

Toone W.M., Morgan B.A., Jones N. Redox control of AP-1-like factors in yeast and beyond // Oncogene.- 2001.- Vol. 20.- P. 2336-2346.

Touati D. Sensing and protecting against superoxide stress in Escherichia coli - how many ways are there to trigger soxRS response? // Redox Report - 2000 - Vol. 5 - P. 287-293.

Tsuzi D., Maeta K., Takatsume Y. et al. Regulation of the yeast phospholipid hydroperoxide glutathione peroxidase GPX2 by oxidative stress is mediated by Yapl and Skn7 // FEBS Lett.- 2004- Vol. 565.-P. 148-154.

Tsvetkov P., Asher G., Reiss V. et al. Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin // Proc. Natl. Acad. Sci. USA.- 2005.- Vol. 102.- P. 5535-5540.

Valerio L.G., Kepa J.K., Pickwell G.V., Quattrochi L.C. Induction of human NAD(P)H:quinone oxidoreductase (NQOl) gene expression by the flavonol quercetin // Toxicol. Lett - 2001- Vol. 119.- P.49-57.

Vasiliou V., Qamar L., Pappa A. et al. Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione // Arch. Biochem. Biophys.- 2003.-Vol. 413.-P. 164-171.

Venugopal R., Jaiswal A.K. Nrfl and Nrf2 positively and c-Fos and Fral negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene // Proc. Natl. Acad. Sci. USA.- 1996.- Vol. 93.- P. 14960-14965.

Venugopal R., Jaiswal A.K. Nrf2 and Nrfl in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes // Oncogene - 1998 - Vol. 17 - P. 3145-3156.

Viarengo A., Burlando B., Ceratto N., Panfoli I. Antioxidant role of metallothioneins: a comparative overview // Cell. Mol. Biol.- 2000.- Vol. 46.- P. 407-417.

Wakabayashi N., Dinkova-Kostova A.T., Holtzclaw W.D. et al. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keapl sensor modified by inducers // Proc. Natl. Acad. Sci. USA.- 2004.- Vol. 101.- P. 2040-2045.

Wakabayashi N., Itoh K., Wakabayashi J. et al. Keapl-null mutation leads to postnatal lethality due to constitutive Nrf2 activation 11 Nat. Genet - 2003 - Vol. 35 - P. 238-245.

Wang B., Williamson G. Transcriptional regulation of the human NAD(P)H:quinone oxidoreductase (NQOl) gene by monofunctional inducers // Biochim. Biophys. Acta - 1996- Vol. 1307- P. 104-110.

Wasserman W.W., Fahl W.E. Functional antioxidant responsive elements // Proc. Natl. Acad. Sci. USA.- 1997.- Vol. 94.- P. 5361-5366.

Woo H.A., Chae H.Z., Hwang S.C. et al. Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation // Science - 2003 - Vol. 300 - P. 653-656.

Woo H.A., Jeong W., Chang T.S. et al. Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins // J. Biol. Chem- 2005- Vol. 280 - P. 3125-3128.

Wu G., Fang Y.Z., Yang S. et al. Glutathione metabolism and its implications for health // J. Nutr. -

- Vol. 134.- P. 489-492.

Wu J.T., Krai J.G. The NF-KB/IkB signaling system: A molecular target in breast cancer therapy // J. Surg. Res.-2005.- Vol. 123.-P. 158-169.

Xu C., Li C.Y., Kong A.N. Induction of phase I, II and III drug metabolism/transport by xenobiotics // Arch. Pharm. Res.- 2005.- Vol. 28.- P. 249-268.

Xu C., Shen G., Chen C. et al. Suppression of NF-kB and NF-KB-regulated gene expression by sul- foraphane and PEITC through IicBa, IKK pathway in human prostate cancer PC-3 cells // Oncogene.- 2005.- Vol. 2.4.- P. 4486-4495.

Yaekashiwa M., Wang L.H. Nrf2 regulates thromboxane synthase gene expression in human lung cells // DNA Cell Biol.- 2003.- Vol. 22.- P. 479-487.

Yang H., Magilnick N., Lee C. et al. Nrfl and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kB and AP-1 // Mol. Cell. Biol - 2005- Vol. 25- P. 5933-5946.

Yang K.-S., Kang S.W., Woo H.A., Hwang S.C., Chae H.Z., Kim K., Rhee S.G. Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid // J. Biol. Chem - 2002 - Vol. 277 - P. 38029-38036.

Yang Y., Cheng J.Z. Singhal S.S. et al. Role of glutathione S-transferases in protection against lipid peroxidation: overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide induced apoptosis and inhibits JNK and caspase 3 activation // J. Biol. Chem - 2001- Vol. 276 - P. 19220-19230.

Yeh C.T., Yen G.C. Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells // Carcinogenesis - 2005- Vol. 26 - P. 2138-2148.

Yoh K., Itoh K., Enomoto A. et al. Nrf2-deficient female mice develop lupus-like autoimmune nephritis// Kidney Int.- 2001 - Vol. 60 - P. 1343-1353.

Yu R., Chen C., Mo Y.Y. et al. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism // J. Biol. Chem.- 2000.- Vol. 275.- P. 39907-39913.

Zhang H., Dickinson D.A., Liu R.M., Forman H.J. 4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways // Free Radie. Biol. Med. - 2005.- Vol. 38.- P. 463-471.

Zhang J., Svehlikova V., Bao Y. et al. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation // Carcinogenesis.- 2003.- Vol. 24.- P. 497-503.

Zhang Y., Gonzalez V., Xu M.J. Expression and regulation of glutathione S-transferase Pl-1 in cultured human epidermal cells // J. Dermatol. Sci. - 2002 - Vol. 30 - P. 205-214.

Zhang Y., Gordon G.B. A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway // Mol. Cancer Ther.- 2004 - Vol. 3 - P. 885-893.

Zheng M., Wang X., Templeton LJ. et al. DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide // J. Bacteriol. - 2001.- Vol. 183 - P. 4562-4570.

Zhu M., Fahl W.E. Functional characterization of transcription regulators that interact with the electrophile response element // Biochem. Biophys. Res. Commun. - 2001.- Vol. 289 - P. 212-219.

Zhu H., Itoh K., Yamamoto M. et al. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species-induced cell injury // FEBS Lett. - 2005.- Vol. 579.- P. 3029-3036.

Zhu M., Zhang Y., Cooper S. et al. Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism // Mol. Carcinog - 2004 - Vol. 41- P. 179-186.

Zipper L.M., Mulcahy R.T. Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes // Biochem. Biophys. Res. Commun. - 2000 - Vol. 278 - P. 484-492.

Zoete V., Rougee M., Dinkova-Kostova A.T. et al. Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital // Free Radie. Biol. Med. - 2004. - Vol. 36.-P. 1418-1423.

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